The mitochondrion in aging and disease - download pdf or read online

By H.D. Osiewacz

ISBN-10: 0123946255

ISBN-13: 9780123946256

ISBN-10: 0123948401

ISBN-13: 9780123948403

Mitochondria, the "power vegetation" of eukaryotic cells, are top identified for the iteration of adenosine triphosphate (ATP), the common mobile "energy foreign money" of the mobile, and the synthesis of alternative crucial parts. Mitochondrial disorder is understood to guide to numerous degenerative problems, ailment, and getting older. The Mitochondrion in getting older and Disease works to resolve the techniques resulting in mitochondrial impairments and of pathways curious about mitochondrial qc and their impression on health and wellbeing and getting older may be addressed.

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1. Mitochondrial biology and mtDNA Mitochondria are subcellular organelles responsible for generation of ATP, the cell’s universal energy carrier, in a process of oxidative phosphorylation. This process is performed by a set of five multisubunit enzyme complexes (I, II, III, IV, and V) called the respiratory chain (RC), which are located on the inner membrane of the mitochondrion (for illustration see Ref. 5). Depending on the metabolic requirement of the cell, the number of mitochondria can vary markedly.

9 MtDNA is maternally inherited in mammals since all the mitochondria from the sperm are destroyed on entry into the ovum. MtDNA is present in multiple copies in all cells. The number of copies of mtDNA varies markedly between cells, with tissues with high energy requirements, such as brain, heart, and skeletal muscle, harboring the largest numbers of mitochondrial genomes. , compact nucleoprotein particles containing from one to a few mtDNA molecules. 2. , loss of large portions of the genome (from a few hundred base pairs to almost the entire mitochondrial genome).

2006;20:1064–1073. 79. Caro P, Go´mez J, Lo´pez-Torres M, et al. Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver. Biogerontology. 2008;9:183–196. 80. Caro P, Gomez J, Sanchez I, et al. Forty percent methionine restriction decreases mitochondrial oxygen radical production and leak at complex I during forward electron flow and lowers oxidative damage to proteins and mitochondrial DNA in rat kidney and brain mitochondria.

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The mitochondrion in aging and disease by H.D. Osiewacz


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