By Jan Barciszewski, Volker A. Erdmann
(Landes Bioscience/Eurekah.com) Polish Academy of Sciences, Poznan, Poland. Takes an in-depth examine the functionality of non-coding RNAs and their hyperlink to molecular biology. Discusses constitution and serve as of the imprinted H19 RNA, brain-specific nonmessenger RNAs, and new developments in RNA learn. DNLM: RNA, untranslated--genetics.
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Extra resources for Non-Coding RNAs: Molecular Biology and Molecular Medicine
French PJ, Bliss TV, O’Connor V. Ntab, a novel noncoding RNA abundantly expressed in rat brain. Neurosci 2001; 108:207-215. 98. Lin Y, Brosius J, Tiedge H. Neuronal BC1 RNA: coexpression with growth-associated protein-43 messenger RNA. Neurosci 2001; 103:465-479. 99. Muslimov IA, Titmus M, Koenig E et al. Transport of neuronal BC1 RNA in Mauthner axons. J Neurosci 2002; 22:4293-4301. 100. Wang Y, Crawford DR, Davies KJ. adapt33, a novel oxidant-inducible RNA from hamster HA-1 cells. Arch Biochem Biophys 1996; 332:255-260.
That is, intronic RNAs may convey secondary information into the system about gene expression status, via efference signals that modulate other parts of the molecular genetic network, through RNA-DNA, RNA-RNA and RNA-protein interactions that regulate chromatin architecture (and epigenetic memory), transcription, splicing, mRNA translation and RNA stability/turnover, among others, for most of which there is experimental evidence (see below). This hypothesis also predicts that introns will be processed post-splicing to produce multiple smaller signals (rather than simply degraded to ribonucleotides), which Introns and Noncoding RNAs: The Hidden Layer of Eukaryotic Complexity 15 will intersect with many different parts of the regulatory circuitry of the cell, and that some (many) genes will have evolved to only produce (noncoding) RNAs, as higher order regulators in the network, thereby generally explaining the expansion of both intronic sequences and ncRNA genes in the higher organisms.
60. Aruscavage PJ, Bass BL. A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing. RNA 2000; 6:257-269. 61. Sun L, Li Y, McCullough AK et al. Intron conservation in a UV-specific DNA repair gene encoded by chlorella viruses. J Mol Evol 2000; 50:82-92. 62. Yatsuki H, Watanabe H, Hattori M et al. 5: long-stretches of unusually well conserved intronic sequences of Kvlqt1 between mouse and human. DNA Res 2000; 7:195-206. 63. Jareborg N, Birney E, Durbin R.
Non-Coding RNAs: Molecular Biology and Molecular Medicine by Jan Barciszewski, Volker A. Erdmann