By M. Hegner, W. Grange (auth.), Wolfgang A. Linke, Henk Granzier, Miklós S. Z. Kellermayer (eds.)
A consultant cross-section of elastic biomolecules is roofed during this quantity, which mixes seventeen contributions from top examine teams. cutting-edge molecular mechanics experiments are defined facing the pliability of DNA and nucleoprotein complexes, titin and titin-like proteins in muscle, in addition to proteins of the cytoskeleton and the extracellular matrix.
The booklet speaks rather to telephone biologists, biophysicists, or bioengineers, and to senior researchers and graduate scholars alike, who're attracted to fresh advances in single-molecule know-how (optical tweezers strategy, atomic strength microscopy), EM imaging, and machine simulation methods to check nanobiomechanics. The findings mentioned right here have redefined our view of the function mechanical indications play in mobile capabilities and feature tremendously helped increase our knowing of organic elasticity in general.
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Extra info for Mechanics of Elastic Biomolecules
2002) themselves . As far as the lack of reversibi lity following the very first stretch in Bennink et al. , 2002). Thus the explanation for the contrasting result s of Bennink et al. (200Ia) lies in the way the two sets of experim ent s were performed: they cannot be directl y compared. Thus, all three papers on stretching chromatin fibers with OT estimate that nucleosome s are unraveled at forces exceeding 20 pN . , 1998; Wuite et al. , 2000), the enzymes that encounter nucleo some s while reading the information in the DNA .
Zlatanov a J and Leuba SH (in press) Chromatin structure and dynami cs: lessons from single molecule approaches. ) Chromatin Structure and Dynam ics: S tateof -the-Art. Elsevier, Amsterdam . Zlatanova J, Leuba SH, Yang G , Bustaman te Cand van Hold e K (1994) Linker DNA accessibility in chromati n fibers of different conformations: a reevaluati on . Proc Na tl Acad S ci USA 91: 5277-5 280. Ziata nova J, Lindsay SM and Leuba SH (2000) Single molecule force spectroscopy in biology using the atomic force microscope.
Chiu W, Ga rner EC a nd Ob rad ovic Z (200 1) Intrinsically disord ered prot ein . J M ol Graph M odel 19: 2659. Essevaz-Rou let B. Bockelm ann U a nd Heslot F (1997) Mechan ical separa tio n of the complementa ry strand s of DNA . 940. Fang Y a nd Hoh JH (1998) Earl y interm ediat es in spermidine-ind uced DNA co ndensa tion on the sur face o f mica. J Am Chern S oc 120: 8903-8 909. Fan g Y. Spisz TS an d Hoh JH (1999) Eth a no l-ind uced structura l tra nsitio ns of DN A on mica. Nucleic Acid ,' Res 27: 1943- 1949.
Mechanics of Elastic Biomolecules by M. Hegner, W. Grange (auth.), Wolfgang A. Linke, Henk Granzier, Miklós S. Z. Kellermayer (eds.)