By Morteza Naghavi (auth.), Morteza Naghavi (eds.)
Despite fresh advances within the analysis and therapy of symptomatic atherosclerosis, to be had conventional screening tools for early detection and remedy of asymptomatic coronary artery ailment are grossly inadequate and fail to spot nearly all of sufferers ahead of the onset of a life-threatening occasion. In Asymptomatic Atherosclerosis: Pathophysiology, Detection and therapy, Dr. Morteza Naghavi and prime specialists from the Society for center assault Prevention and Eradication (SHAPE) current a brand new paradigm for the screening and first prevention of asymptomatic atherosclerosis.
The textual content specializes in exact, but underutilized, measures of subclinical atherosclerosis, significantly coronary artery calcium scanning and carotid intima-media thickness dimension. The authors introduce a entire method of picking out the susceptible sufferers (asymptomatic contributors prone to a close to destiny antagonistic event). extra chapters speak about destiny instructions in the direction of containing the epidemic of atherosclerotic heart problems utilizing leading edge strategies equivalent to preemptive interventional remedies (bioabsorbable stents) for stabilization of weak atherosclerotic plaques, mass unconditional Polypill remedy for population-based hazard aid, and eventually vaccination thoughts to avoid the improvement of atherosclerosis.
Up-to-date and authoritative, Asymptomatic Atherosclerosis: Pathophysiology, Detection, and therapy is a must have for any heart specialist or basic care healthcare professional who needs to perform smooth preventive cardiology and deal with the expanding variety of asymptomatic atherosclerotic patients.
• Outlines extra actual measures of possibility (coronary artery calcium and carotid intima-media thickness) than conventional hazard elements (total ldl cholesterol, cholesterol, HDL cholesterol)
• provides new multipronged thoughts to assist within the early detection and remedy of excessive danger asymptomatic patients
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Additional resources for Asymptomatic Atherosclerosis: Pathophysiology, Detection and Treatment
The search for the vulnerable patient must follow a pyramid approach, the base of which would start from a comprehensive non-invasive, non-imaging assessment of vascular health along with risk factor measurement. The next step would be non-invasive imaging of atherosclerosis (structure and activity) followed by invasive procedures if risk of an eminent event is expected. • Longitudinal natural study of vulnerable plaque and vulnerable patients are needed to compare the proposed pyramid-based approach versus the status quo.
Inflammation promotes thrombosis and vice versa . Extensive atherosclerosis may be associated with increased blood thrombogenicity, but the magnitude of thrombogenicity varies from patient to patient, and unstable plaques are much more thrombogenic than stable ones (Table 7). Some platelet polymorphisms, such as glycoprotein IIIa P1(A2) , Ib agene-5T/C Kozak , high factor V and factor VII clotting , have been reported as independent risk factors for myocardial infarction. Reiner et al.
Circulation. 2003;107:113–119. 43. Krinsky GA, Freedberg R, Lee VS, et al. Innominate artery atheroma: a lesion seen with gadolinium-enhanced MR angiography and often missed by transesophageal echocardiography. Clin Imaging. 2001;25:251–257. 44. Bonk RT, Schmiedl UP, Yuan C, et al. Time-of-flight MR angiography with Gd-DTPA hexamethylene diamine co-polymer blood pool contrast agent: comparison of enhanced MRA and conventional angiography for arterial stenosis induced in rabbits. J Magn Reson Imaging.
Asymptomatic Atherosclerosis: Pathophysiology, Detection and Treatment by Morteza Naghavi (auth.), Morteza Naghavi (eds.)