By Harald Kropshofer, Anne B. Vogt
This novel, multidisciplinary guide highlights contemporary facts that antigen featuring cells (APCs) are usually not merely key avid gamers within the initiation or prevention of an antigen-specific T lymphocyte-mediated adaptive immune reaction, but in addition severe regulators and integrators within the interaction among our innate and adaptive immune system.Structured in a transparent technique to let entry to a really extensive readership, the publication is written from the perspective of a biochemist, immunologist, and scientist with event in drug improvement. It covers all telephone forms fascinated by antigen presentation, offering the most recent immunological proof with a spotlight on drug improvement. sponsored via a thesaurus explaining all very important technical phrases, this brief yet entire reference covers uncomplicated introductory points correct as much as information for complex experts.
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Extra resources for Antigen Presenting Cells: From Mechanisms to Drug Development
Viret C, He X, Janeway CA Jr. Altered positive selection due to corecognition of floppy peptide/MHC II conformers supports an integrative model of thymic selection. Proc. Natl. Acad. Sci. A. 2003, 100, 5354–5359. Huang JC, Han M, Minguela A, Pastor S, Qadri A, Ward ES. T cell recognition u of distinct peptide: I-A conformers in murine experimental autoimmune encephalomyelitis. J. Immunol. 2003, 171, 2467–2477. Hulsmeyer M, Fiorillo M, Fiorillo, MT, Bettosini F, Sorrentino R, Saenger W, Ziegler A, Uchanska-Ziegler B.
Our colleagues in the Immunology Program at Washington University have provided us with much encouragement and help. The National Institutes of Health, and the National Institute for Allergy and Infectious Disease, supported these investigations. References References 1 Unanue ER. Perspective on antigen pro- 2 3 4 5 6 7 8 9 10 cessing and presentation. Immunol. Rev. 2002, 185, 86–102. Unanue E, Byersdorfer C, Carrero J, Levisetti M, Lovitch S, Pu Z, Suri A. Antigen presentation. Autoimmune diabetes and Listeria – What do they have in common?
Peptides of 8–10 amino acids are loaded onto MHC class I heavy chain (HC)/ b2-microglobulin (b2m) dimers that are tethered to TAP by means of the dedicated chaperone tapasin. Tapasin also recruits the oxidoreductase ERp57, which might isomerize the MHC-I a2 domain disulfide bridge during peptide loading. Together with the lectin-like chaperone calreticulin (CRT), these components form the peptide-loading complex (PLC). Tapasin seems to retain MHC-I in a peptide-receptive conformation and its editing function results in an optimized affinity of MHC-I ligands and improved stability of cell surface HC/ b2m/peptide complexes.
Antigen Presenting Cells: From Mechanisms to Drug Development by Harald Kropshofer, Anne B. Vogt