By Bruno Gander, Hans P Merkle, Giampietro Corradin
This article offers an up to date evaluate of modern advancements during this box, experiences new tendencies in vaccine improvement courses, and emphasizes the necessities and significance of assorted vaccine supply structures.
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Additional info for Antigen Delivery Systems: Immunological and Technological Issues (Drug Targeting and Delivery)
1990), one may expect that>1000 determinants can be simultaneously displayed by an APC. Overrepresentation of determinants would limit presentation of others and thereby may hamper the detection of scarce determinants. This happens when APC are artificially saturated with antigen, a situation which is physiologically avoided (see below). Few studies have analyzed the antigenicity of peptides displayed by class II MHC molecules. , 1995). , 1995). , 1996). , 1994) revealed motifs for class II MHC-bound peptides.
The former recognize complexes between fragments of antigen and class I MHC molecules, while the latter recognize complexes between fragments of antigen and class II MHC molecules. In short, class I MHC molecules preferentially display peptides which derive from antigens synthesized within the cell, most notably the viruses, whereas class II MHC molecules bind peptides derived from proteins of the extracellular compartment or internalized by the cells. Although oversimplified, this model nevertheless indicates that these two systems of antigen sampling endow the T cells with the capacity to detect pathogens which invade the organism using extremely varied strategies.
Controlled Release, 41, 131–145. S. and Singh, M. (1995) Synthetic delivery system for tuberculosis vaccines: immunological evaluation of the M. tuberculosis 38 kDa protein entrapped in biodegradable PLG microparticles. Vaccine, 13, 1576–1582. , Jones, C. and Sesardic, D. (1996a) Physicochemical and immunological studies on the stability of free and microsphere-encapsulated tetanus toxoid in vitro. Vaccine, 14, 1205–1213. J. and Sesardic, D. (1996b) Estimation of antigenic tetanus toxoid extracted from biodegradable microspheres.
Antigen Delivery Systems: Immunological and Technological Issues (Drug Targeting and Delivery) by Bruno Gander, Hans P Merkle, Giampietro Corradin