Download PDF by Daniel Erik Otzen: Amyloid Fibrils and Prefibrillar Aggregates: Molecular and

By Daniel Erik Otzen

ISBN-10: 3527332006

ISBN-13: 9783527332007

ISBN-10: 3527654186

ISBN-13: 9783527654185

Summing up virtually a decade of biomedical examine, this topical and eagerly awaited guide is the 1st reference at the subject to include fresh breakthroughs in amyloid study.
the 1st half covers the structural biology of amyloid fibrils and pre-fibrillar assemblies, together with an outline of present versions for amyloid formation. the second one half seems to be on the analysis and biomedical research of amyloid in people and in animal versions, whereas the ultimate part discusses pharmacological methods to manipulating amyloid and in addition seems to be at its physiological roles in decrease and better organisms.

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24. 25. the free-energy landscapes of proteins. Philos. Trans. R. Soc. London Ser. A, 363, 433–450. A. (2011) Observation of spatial propagation of amyloid assembly from single nuclei. Proc. Natl. Acad. Sci. , 108, 14746–14751. C. (1997) Common core structure of amyloid fibrils by synchrotron X-ray diffraction. J. Mol. , 273, 729–739. R. (2002) The protofilament structure of insulin amyloid fibrils. Proc. Natl. Acad. Sci. , 99, 9196–9201. , and Eisenberg, D. (2005) Structure of the cross-β spine of amyloid-like fibrils.

C. (1997) Common core structure of amyloid fibrils by synchrotron X-ray diffraction. J. Mol. , 273, 729–739. R. (2002) The protofilament structure of insulin amyloid fibrils. Proc. Natl. Acad. Sci. , 99, 9196–9201. , and Eisenberg, D. (2005) Structure of the cross-β spine of amyloid-like fibrils. Nature, 435, 773–778. , and Tycko, R. (2002) A structural model for Alzheimer’s beta -amyloid fibrils based on experimental constraints from solid state NMR. Proc. Natl. Acad. Sci. , 99, 16742. M. Atomic resolution structure of a cross-β amyloid fibril.

M. (2009) An analytical solution to the kinetics of breakable filament assembly. Science, 326, 1533–1537. S. (2004) Mechanism of prion propagation: amyloid growth occurs by monomer addition. , 2, e321. , Wolfe, 17 18 1 The Amyloid Phenomenon and Its Significance 34. 35. 36. 37. 38. 39. 40. 41. J. (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature, 416, 535–539. G. (2009) Soluble fibrillar oligomer levels are elevated in Alzheimer’s disease brain and correlate with cognitive dysfunction.

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Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological Properties by Daniel Erik Otzen


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