Download e-book for iPad: Alternative Splicing and Disease (Progress in Molecular and by Philippe Jeanteur

By Philippe Jeanteur

ISBN-10: 3540344489

ISBN-13: 9783540344483

Splicing of fundamental RNA transcript is a quasi-systematic step of gene expression in larger organisms. this can be the 1st booklet to focus on the clinical implications, i.e. ailments, attributable to substitute splicing. replacement splicing not just tremendously raises protein range but in addition bargains a variety of possibilities for aberrant splicing occasions with pathological results. The booklet additionally outlines attainable goals for treatment.

Show description

Read Online or Download Alternative Splicing and Disease (Progress in Molecular and Subcellular Biology) PDF

Similar molecular biology books

Download e-book for iPad: Volume 70, Advances in Enzymology and Related Areas of by Alton Meister

Enzymes are used often in enhancing proteins for specialised makes use of. those books hide the most recent advances during this box and its purposes within the box of molecular biology. common evaluation of the most recent advancements within the box of molecular biology. this can be newest quantity within the profitable Wiley sequence on enzymology as utilized to molecular biology.

Read e-book online Cell Physiology Sourcebook, Third Edition: A Molecular PDF

This thoroughly revised and up-to-date resource ebook presents accomplished and authoritative insurance of telephone body structure and membrane biophysics. meant basically as a textual content for complex undergraduate and graduate scholars and as a reference for researchers, this multidisciplinary publication contains numerous new chapters and is a useful reduction to scientists drawn to telephone body structure, biophysics, mobile biology, electrophysiology, and cellphone signaling.

Cheryl D. Helgason, Cindy L. Miller's Basic Cell Culture Protocols Methods in Molecular Biology - PDF

During this totally revised version of a longtime vintage, professional researchers and clinicians describe in step by step aspect up to date innovations for the isolation and progress of significant fundamental telephone kinds, similar to kidney proximal tubule cells, hepatocytes, keratinocytes, and cardiomyocytes. The authors provide comfortably reproducible new tools for the differentiation of embryonic stem (ES) cells into a variety of hematopoietic mobilephone varieties, for fetal thymic organ tradition, and for the isolation and tradition of specialised mobilephone forms, reminiscent of mammary progenitor cells, skeletal muscle myofibers, mesenchymal cells, neural stem cells, hematopoietic cells, stromal mobilephone traces, and endothelial cells.

Download e-book for iPad: Pathways of a Cell Biologist: Through Yet Another Eye by Shinya Inoué

This publication is the autobiography of Shinya Inoué, tracing his existence from youth to the current. even though he has made many contributions to technological know-how, maybe the main outstanding one contains the visualization of dynamics in residing cells through a polarizing gentle microscope, an innovation that modified the face of telephone biology.

Additional info for Alternative Splicing and Disease (Progress in Molecular and Subcellular Biology)

Sample text

2003) Shen et al. (1991) Baudry et al. (2000) Ge et al. (2000) Kwabi-Addo et al. (2001) Lin et al. (1998) NOS Ich-1 ischemia Catania et al. (2001) Daoud et al. 1 Gene Transfer Methods Type I and II mutations either destroy splice sites or activate cryptic splice sites. Antisense nucleic acids can suppress point mutations and promote the formation of the normal gene products. Special chemistries were devised to prevent RNAseH-mediated cleavage of the RNA and to lower toxicity (Sazani and Kole 2003).

Ann Hematol 78: 472–474 Methods and Platforms for the Quantification of Splice Variants 23 Kalbfuss B, Mabon SA, Misteli T (2001) Correction of alternative splicing of tau in frontotemporal dementia and parkinsonism linked to chromosome 17. J Biol Chem 276: 42986–42993 Kampa D, Cheng J, Kapranov P, Yamanaka M, Brubaker S, Cawley S, Drenkow J, Piccolboni A, Bekiranov S, Helt G, Tammana H, Gingeras TR (2004) Novel RNAs identified from an in-depth analysis of the transcriptome of human chromosomes 21 and 22.

2005) Badano et al. (2006) Methionine synthase TCAGCCTGAGAGGA TCAGCCCGAGAGGA GGCCTTCG GGCCTTTG Matern et al. (2003) Short/branched-chain GAGTGGATGGGGG GAGTGGGTGGGGG acyl-CoA dehydrogenase Reference 2-methylbutyryl-coa dehydrogenase deficiency/ short/branched-chain acyl-coa dehydrogenase (SBCAD) Homocystinuria Mutation Gene Disease Table 1. Examples of enhancer mutations involved in human diseases. The table lists examples of mutations in regulatory motifs that cause aberrant splicing. uk/asd/).

Download PDF sample

Alternative Splicing and Disease (Progress in Molecular and Subcellular Biology) by Philippe Jeanteur

by John

Rated 4.04 of 5 – based on 4 votes