Download PDF by Theodore Peters Jr.: All About Albumin: Biochemistry, Genetics, and Medical

By Theodore Peters Jr.

ISBN-10: 0125521103

ISBN-13: 9780125521109

The 1st of its sort, All approximately Albumin summarizes the chemistry, genetics, metabolism, medical implications, and advertisement points of albumin. It presents the main up to date sequences, buildings, and compositions of many species, and comprises greater than 2000 references.

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Extra resources for All About Albumin: Biochemistry, Genetics, and Medical Applications

Sample text

1989b), and showed that it closely agreed with the curve obtained by titration. II. Tertiary Structure and Physical Chemical Behavior 47 Table 2-6, modified from Foster with current analytical data, lists the numbers of potentially ionizable groups and their average intrinsic pK values used in reconstructing the titration curves of HSA and BSA from theoretical considerations. The total numbers for each amino acid type are in excellent agreement with to the values from the definitive amino acid composition (Table 2-1), values that were not available to Tanford or to Foster.

Albumin Molecule: Structure and Chemistry ultrasonic spectroscopy and found that expansion and helix-coil transitions relate to pressure wave absorptions at 200 kHz, corresponding to times of 5 lasec for these transformations. Proton transfers of carboxyl and phenolic groups resonated at 500 nsec, and of amino groups at 20 nsec. Molecular oxygen, a quencher of tryptophan fluorescence, can enter the 10-A crevice between helices h l and h2 (Fig. 2-llA), beneath which lies the sole tryptophan of human albumin, within 6 nsec (Gurd and Rothgeb, 1979).

2. Size and Shape in Solution Albumin molecules show birefringence of flow; that is, they tend to align in a rapidly flowing stream like logs in a river (Edsall and Foster, 1948). The viscosity of albumin solutions, although not as high as that of more fibrous proteins such as fibrinogen, is significantly greater than would be the case if its molecule were spherical in shape. 5:1--a rather stubby cigar to be sure; a closer analogy might be the streamlined hull of an attack submarine (Fig. 2-5).

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All About Albumin: Biochemistry, Genetics, and Medical Applications by Theodore Peters Jr.


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