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Menconi, P. Polgar, The participation of hydroperoxides and oxygen radicals in the control of prostaglandin synthesis, ~ Biol. Chem. 258:6855-6857 (1983). 27. A. J. M. A. F. J. Corey, Functional characterization of synthetic leukotriene B and its stereochemical isomers, J. Exp. Med. 154:1243-1248 (1981). 28. E. Pirotsky, E. Ninio, J. Bidault, P. Pfister, J. Benveniste, Biosynthesis of platelet-activating factor. VI. Precursor of platelet-activating factor and acyl transferase activity in isolated rat kidney cells, Lab.

At 37 0 C in the presence of 50 nM [ H) AA. 28 are, in fact, the end-products detected in vitro but they deriv~ from hydro- peroxy fatty acids: 12- and l5-HPETE which are reduced into HETE by the peroxidases present in glomerular cells. A. 1 per tuft (36), or bone marrow-derived macrophages infiltrating the Bowman's space and the mesangium during experimental nephrotoxic serum nephritis (37,38) and glomerulonephritis of se~um sickness (39). The mechanism of accumulation of macrophages in diseased glomeruli remains uncertain: immune adherence via Fc receptors on macrophages (40) or chemotaxis involving complement fractions (41), fibrin deposition (42) or products derived from collagen breakdown (43).

A. Cohn, Secretion of leukotriene C and other arachidonic acid metabolites by macrophages challenged with immunoglobulin E immune complexes, ~ Exp. Med. 156:1077-1086 (1982). 49. H. Rabinovitch, J. Durand, M. Rigaud, F. C. Breton, Transformation of arachidonic acid into monohydroxy-eicosatetraenoic acids by mouse peritoneal macrophages, Lipids 16:518-524 (1981). 50. N. W. Ford-Hutchinson, The production and characterization of products of the lipoxygenase enzyme system released by rat peritoneal macrophages, Prostaglandins 20:1007-1019 (1980).

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Aircraft Profile No. 23: The Messerschmitt Bf 110 by Martin C. Windrow


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