By Pekka Lappalainen
The actin cytoskeleton performs a valuable function in lots of mobile procedures together with phone motility, cytokinesis, endocytosis and phagocytosis. The constitution and dynamics of the actin cytoskeleton is regulated via a lot of proteins that engage with monomeric and/or filamentous actin. Actin monomer binding proteins offers a finished view on actin monomer-binding proteins and the mechanisms through which they give a contribution to actin dynamics and numerous actin-dependent mobile techniques. This new name includes chapters that describe the elemental mechanisms of actin dynamics in addition to the structural ideas during which a variety of actin-binding proteins engage with actin.
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Extra resources for Actin-Monomer-Binding Proteins
Microscopic evidence that actin-interacting protein 1 actively disassembles actin-depolymerizing factor/Cofilin-bound actin filaments. J Biol Chem 2004; 279(14):14207-14212. 108. Voegdi W C , Madrona AY, Wilson DK. T h e structure of A i p l p , a W D repeat protein that regulates Cofihn-mediated actin depolymerization. J Biol Chem 2003; 278(36):34373-34379. 109. O h SH, Adler HJ, Raphael Y et al. W D R l colocalizes with ADF and actin in the normal and noise-damaged chick cochlea. J Comp Neurol 2002; 448(4):399-409.
Actin-based motility as a self-organized system: Mechanism and reconstitution in vitro. C R Biol 2003; 326(2):161-170. ADF/Cofilin Proteins 27 119. Laurent V, Loisel T P , Harbeck B et al. Role of proteins of the EnaA^ASP family in actin-based motility of Listeria monocytogenes. J Cell Biol 1999; 144(6): 1245-1258. 120. Romero S, Le Clainche C, Didry D et al. Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis. Cell 2004; 119(3):4l9-429.
Polarity can be restored to these cells by coexpressing the constitutively active S3A-AC mutant. Not surprisingly, both LIMKl and SSH-IL are required for maintenance of directional migration in fibroblasts. ^^^ The role of AC proteins in neuronal growth cone motility and response to guidance cues has also been studied. A recent investigation into the mechanism by which the neurotrophin BDNF (brain derived neurotrophic factor) mediates growth cone filopodial extension has implicated AC as an important player in this process.
Actin-Monomer-Binding Proteins by Pekka Lappalainen