By Pierre Hainaut, Klas G. Wiman
P53 has emerged as a key tumor suppressor and critical objective for novel melanoma remedy. This booklet, written via world-leading p53 researchers together with lots of those that have formed the sphere over the last 25 years, presents targeted insights into the development of the sphere and the clients for higher melanoma analysis and remedy sooner or later.
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Extra resources for 25 Years of P53 Research
Interestingly, the tetrameric status of p53 requires a larger hydrophobic side chain at residue 341 than 344. An inversion of this relationship results in dimeric p53. The tetramerization domain has been the focus of research aimed at enabling exogenously added p53 to avoid forming inactive cotetramers with inactive endogenous mutant forms of p53 that are often present at high levels in tumors. , 1996). In addition, there is some evidence that the tetramerization of p53 can be regulated. Sakaguchi et al.
EMBO, 1999. 18: 1805-1814. , Sancar A. Preferential binding of ATR protein to UV-damaged DNA. Proceedings of the National Academy of Sciences USA, 2002. 99: 6673-6678. M. Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science, 1990. 248: 76-79. , Harlow E. Cellular targets for transformation by the adenovirus E1A proteins. Cell, 1989. 56: 67-75. J. The p53-mdm-2 autoregulatory feedback loop. Genes and Development, 1993. 7: 1126-1132. , Beach D. p21 is a universal inhibitor of cyclin kinases.
2003). Focusing on the DNA contact class of p53 mutations instead, Wieczorek et al. reasoned that secondary mutations which introduced novel interactions between amino acid side chains and the phosphate backbone might act as suppressor mutations. Therefore, they singly mutated several residues in p53 to arginine or lysine. , 1996). TETRAMERIZATION DOMAIN The oligomerization domain is located between amino acids 320-360 (reviewed in Chene, 2001). This domain is responsible for the mostly tetrameric state of p53 in solution and along with the basic region comprises the minimal transforming domain.
25 Years of P53 Research by Pierre Hainaut, Klas G. Wiman